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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Psychopharmacology (Berl). 2020 Sep 7;237(12):3715–3728. doi: 10.1007/s00213-020-05649-y

Figure 2.

Figure 2.

Experimental timeline (A) and percent body weight gain (B). Experimental timeline from commencement of the unpredictable chronic mild stress (UCMS) procedure to euthanasia. The UCMS procedure lasted for 28 days. The KOR antagonist aticaprant (10 mg/kg, i.p.) was administered daily 11 times. Treatment began at 23 days of UCMS and lasted five days post UCMS cessation during the first course of behavioral assessment. Abbreviations: nest building (NB); sucrose preference test (SPT); social interaction (SI); light-dark test (LD); forced swim test (FST); and hot plate test (HP). Body weight data is shown in two-day intervals separately for the UCMS only period (UCMS), aticaprant period (Aticaprant), and recovery from both the UCMS and aticaprant periods (Recovery). All groups were evenly matched in terms of body weight prior to stress exposure: (NS/Vehicle: n=13; 26.4 g ± 0.5; NS/Aticaprant: n=12; 25.6 g ± 0.5; UCMS/Vehicle: n=12; 25.6 g ± 0.7; UCMS/Aticaprant: n=13; 26.0 g ± 0.5).