Table 6.

Association of Meibomian gland features with Sjogren’s disease in upper and lower lids

	Upper Lid					Lower Lid
	Sjogren’s Disease
Meibomian gland feature	Total n=394	No n=367	On-going n=27	* p-value	**PMC	Total n=498	No n=455	On-going n=43 *	* p-value	**PMC
Total, mean (SD)	8.98 (2.8)	9.00	8.59	0.39	0.83	7.20 (1.9)	7.22	7.01	0.81	0.99
Distorted, mean (SD)	4.20 (2.3)	4.26	3.39	0.03	0.37	1.56 (1.5)	1.59	1.22	0.32	0.99
Tortuous, mean (SD)	0.83 (1.2)	0.85	0.57	0.22	0.83	0.06 (0.3)	0.06	0.06	0.99	0.99
Hooked, mean (SD)	0.36 (0.7)	0.36	0.43	0.53	0.83	0.05 (0.3)	0.05	0.02	0.45	0.99
Short, mean (SD)	2.97 (2.2)	2.94	3.43	0.38	0.83	1.66 (1.8)	1.71	1.14	0.02	0.29
Thick, n(%)	38 (10%)	(10%)	(0%)	·	·	10 (2%)	(2%)	(2%)	·	·
Thin, mean (SD)	0.33 (0.7)	0.34	0.26	0.48	0.83	0.08 (0.3)	0.07	0.14	0.47	0.99
Overlapping, mean (SD)	0.46 (0.7)	0.47	0.43	0.83	0.83	0.06 (0.3)	0.05	0.07	0.60	0.99
Ghost, mean (SD)	0.86 (1.7)	0.89	0.33	0.006	0.07	0.55 (1.4)	0.54	0.66	0.58	0.99
Dropout gland, mean (SD)	0.07 (0.5)	0.06	0.11	0.59	0.83	0.17 (0.5)	0.17	0.19	0.74	0.99
Tadpoling, n(%)	24 (6%)	(7%)	(0%)	·	·	5 (1%)	(1%)	(2%)	·	·
Abnormal gap, n(%)	106 (27%)	(27%)	(22%)	0.31	0.83	2 (0%)	(0%)	(0%)	·	·
No extension to lid margin, n(%)	16 (4%)	(4%)	(0%)	·	·	27 (5%)	(6%)	(0%)	·	·
Fluffy areas, n(%)	43 (11%)	(11%)	(7%)	0.52	0.83	32 (6%)	(6%)	(9%)	0.60	0.99
Composite score, mean (SD)	23.7 (10.0)	24.01	19.25	0.004	0.051	13.1 (8.4)	13.13	12.92	0.76	0.99
Percent dropout area, mean (SD)
Including ghost glands and fluffy areas	0.23 (0.2)	0.23	0.18	0.31	0.83	0.32 (0.2)	0.32	0.34	0.84	0.99
Excluding ghost glands and fluffy areas	0.11 (0.1)	0.11	0.13	0.28	0.83	0.19 (0.1)	0.19	0.19	0.99	0.99

^*Adjusted for age and sex; p-values not adjusted for multiple comparisons

^**Adjusted for multiple comparisons