Table 2.
Echocardiographic Characteristics Stratified by Comorbidity Burden in PROMIS-HFpEF
| Characteristic | Comorbidity burden (number of comorbidities) | P-value | ||
|---|---|---|---|---|
| 0–2 (n=67) |
3–4 (n=110) |
5+ (n=51) |
||
| LVEF, % | 59 (55–65) | 59 (55–63) | 61 (56–65) | 0.35 |
| LVEDVi, ml/m2 | 41.8 (32.6–52.7) | 41.7 (34.3–49.0) | 38.9 (32.9–50.2) | 0.79 |
| LVESVi, ml/m2 | 16.7 (11.6–22.0) | 16.8 (13.5–20.6) | 15.9 (12.3–19.3) | 0.65 |
| LVMi, g/m2 | 103 (81–119) | 104 (83–125) | 108 (85–133) | 0.37 |
| Relative wall thickness | 0.43 (0.38–0.51) | 0.44 (0.39–0.52) | 0.49 (0.43–0.56) | 0.02 |
| LAVi, ml/m2 | 35.9 (29.9–43.6) | 39.7 (30.9–47.7) | 39.0 (31.5–42.9) | 0.23 |
| Mitral E, cm/s | 89 (75–105) | 95 (81–114) | 108 (80–129) | 0.04 |
| e’ (average), cm/s | 8.2 (6.5–9.8) | 8.2 (6.9–10.5) | 8.0 (6.2–9.9) | 0.43 |
| E/e’ ratio (average) | 11.7 (9.1–16.1) | 12.1 (8.9–16.5) | 13.8 (10.8–16.7) | 0.28 |
| RVEDAi, mm2/m2 | 94.5 (79.1–107.8) | 101.6 (84.0–117.8) | 98.3 (81.8–119.7) | 0.07 |
| RVESAi, mm2/m2 | 50.3 (44.5–63.8) | 58.4 (47.8–75.1) | 53.8 (46.5–74.5) | 0.14 |
| RV wall thickness, cm | 0.46 (0.43–0.50) | 0.47 (0.43–0.53) | 0.51 (0.47–0.56) | <0.001 |
| TAPSE, cm | 1.9 (1.6–2.2) | 1.7 (1.5–2.1) | 1.7 (1.5–1.9) | 0.005 |
| RV s’ velocity, cm/s | 12.5 (9.7–14.4) | 11.2 (9.9–12.9) | 10.1 (9.1–12.4) | 0.01 |
| TR velocity, cm/s | 297 (274–325) | 293 (263–329) | 313 (271–362) | 0.18 |
| LV GLS, %-unit | 17.5 (14.1–19.4) | 16.2 (13.1–18.4) | 14.6 (12.4–17.1) | 0.008 |
| RV free wall strain, %-unit | 23.9 (20.5–28.0) | 21.0 (17.8–24.7) | 20.0 (15.5–24.6) | <0.001 |
| LA reservoir strain, %-unit | 25.2 (16.0–36.2) | 17.5 (12.5–31.6) | 18.0 (12.2–27.3) | 0.007 |
Values represent median (25th-75th percentile). Strain values are shown as absolute values for ease of interpretation. E/e’ ratio and e’ velocity represent average of septal and lateral mitral annulus values.
LVEDVi = left ventricular end diastolic volume index; LVESVi = left ventricular end systolic volume index; LVEF = left ventricular ejection fraction; LVMi = left ventricular mass index; RWT = relative wall thickness; LAVi =left atrial volume index; RVEDAi = right ventricular end diastolic area index; RVESAi = right ventricular end systolic area index; RV = right ventricular; TAPSE = tricuspid annular plane systolic excursion; TR = tricuspid regurgitation; GLS = global longitudinal strain of the left ventricle; LA = left atrial.