Table I.
Patient characteristics at study entry and during follow-up
| Characteristic | Statistic | Baseline | Year 1 | Year 2 | Year 3 | Year 4 | Year 5 | Year 6 | Year 7 | Year 8 | Year 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Participants | N | 350 | 229 | 179 | 151 | 102 | 73 | 56 | 47 | 37 | 18 |
| Visits per participant | Mean (SD) | 3.55 (2.48) | – | – | – | – | – | – | – | – | – |
| Median (IQR) | 3 (4) | – | – | – | – | – | – | – | – | – | |
| Min, max | 1,11 | – | – | – | – | – | – | – | – | – | |
| Phenotype | SZ | 32 (10.1%) | – | – | – | – | – | – | – | – | – |
| ZZ | 286 (89.9%) | – | – | – | – | – | – | – | – | – | |
| Age (years) | N | 350 | 229 | 179 | 151 | 102 | 73 | 56 | 47 | 37 | 18 |
| Mean (SD) | 6.05 (5.49) | 6.82 (5.09) | 7.31 (4.87) | 8.91 (4.99) | 9.83 (4.85) | 9.99 (4.21) | 10.86 (4.04) | 11.52 (3.75) | 12.96 (3.97) | 13.24 (4.24) | |
| Median (IQR) | 4.23 (7.98) | 5.59 (7.38) | 5.93 (6.38) | 7.7 (7.07) | 8.64 (7.27) | 9.04 (5.3) | 9.94 (5.58) | 10.72 (4.49) | 12.79 (4.76) | 12.13 (4.25) | |
| Min, max | 0.12, 24.87 | 0.96, 22.48 | 1.77, 22.85 | 2.78, 23.9 | 4.05, 24.96 | 4.95, 25.97 | 6.06, 24.54 | 7.35, 25.79 | 8.25, 26.88 | 9.77, 28.07 | |
| Age group (years) | 0-<5 | 191 (54.6%) | 107 (46.7%) | 77 (43%) | 42 (27.8%) | 13 (12.7%) | 1 (1.4%) | – | – | – | – |
| 5-<10 | 83 (23.7%) | 70 (30.6%) | 60 (33.5%) | 56 (37.1%) | 47 (46.1%) | 43 (58.9%) | 28 (50%) | 20 (42.6%) | 11 (29.7%) | 2 (11.1%) | |
| 10-<15 | 43 (12.3%) | 31 (13.5%) | 25 (14%) | 31 (20.5%) | 26 (25.5%) | 23 (31.5%) | 21 (37.5%) | 20 (42.6%) | 18 (48.6%) | 13 (72.2%) | |
| 15-<20 | 28 (8%) | 17 (7.4%) | 13 (7.3%) | 17 (11.3%) | 12 (11.8%) | 4 (5.5%) | 5 (8.9%) | 5 (10.6%) | 6 (16.2%) | 2 (11.1%) | |
| 20-<25 | 5 (1.4%) | 4 (1.7%) | 4 (2.2%) | 5 (3.3%) | 4 (3.9%) | 1 (1.4%) | 2 (3.6%) | 1 (2.1%) | 1 (2.7%) | – | |
| ≥25 | – | – | – | – | – | 1 (1.4%) | – | 1 (2.1%) | 1 (2.7%) | 1 (5.6%) | |
| Ethnicity | Hispanic | 21 (6.1%) | 15 (6.6%) | 13 (7.3%) | 9 (6%) | 8 (7.8%) | 5 (6.8%) | 3 (5.4%) | 4 (8.5%) | 3 (8.1%) | 3 (16.7%) |
| Non-Hispanic | 324 (93.9%) | 212 (93.4%) | 165 (92.%) | 141 (94%) | 94 (92.2%) | 68 (93.2%) | 53 (94.6%) | 43 (91.5%) | 34 (91.9%) | 15 (83.3%) | |
| Sex | Male | 211 (60.5%) | 144 (62.9%) | 112 (62.6%) | 86 (57%) | 61 (59.8%) | 39 (53.4%) | 32 (57.1%) | 22 (46.8%) | 20 (54.1%) | 11 (61.1%) |
| Female | 138 (39.5%) | 85 (37.1%) | 67 (37.4%) | 65 (43%) | 41 (40.2%) | 34 (46.6%) | 24 (42.9%) | 25 (53.2%) | 17 (45.9%) | 7 (38.9%) | |
| Race | White | 322 (93.6%) | 210 (92.5%) | 167 (93.3%) | 140 (92.7%) | 96 (94.1%) | 70 (95.9%) | 52 (92.9%) | 43 (91.5%) | 34 (91.9%) | 17 (94.4%) |
| Black | 3 (0.9%) | 3 (1.3%) | 1 (0.6%) | 1 (0.7%) | – | – | – | – | – | – | |
| Other | 19 (5.5%) | 14 (6.2%) | 11 (6.1%) | 10 (6.6%) | 6 (5.9%) | 3 (4.1%) | 4 (7.1%) | 4 (8.5%) | 3 (8.1%) | 1 (5.6%) |