Table 3.
Matched Sibling Donor | Matched Unrelated Donor | |||
---|---|---|---|---|
Characteristics | Coefficient | P value | Coefficient | P value |
G-CSF | 0.18 | 0.78 | −1.9 | 0.02 |
Gender: Male | 0.9 | 0.10 | 0.3 | 0.59 |
Race: Caucasian | −2.8 | 0.003 | −2.1 | 0.16 |
Race: African American | −2.5 | 0.09 | −0.4 | 0.86 |
Ethnicity: Hispanic (vs non- Hispanic) | 1.8 | 0.02 | 3.5 | 0.008 |
Performance score <90 | 1.1 | 0.05 | 2.7 | <.001 |
HCT-comorbidity index ≥3 | 0.5 | 0.35 | 0.8 | 0.23 |
CMV Positive/Negative | 1.3 | 0.12 | −0.2 | 0.83 |
CMV Negative/Positive | 0.4 | 0.50 | −0.2 | 0.82 |
CMV Negative/Negative | 0.7 | 0.35 | 0.2 | 0.77 |
Disease: AML | −0.7 | 0.29 | −0.8 | 0.33 |
Disease: ALL | −0.8 | 0.44 | −0.7 | 0.60 |
High/very high disease risk index | 2.2 | 0.10 | −0.2 | 0.86 |
Intermediate disease risk index | 2.6 | 0.04 | −0.7 | 0.65 |
Time to transplant from diagnosis(< 1 year) | −0.6 | 0.31 | −0.2 | 0.72 |
Period of transplant 2007-2011 | 1.3 | 0.03 | 1.4 | 0.04 |
TBI containing myeloablative regimen | 1.4 | 0.04 | 1.9 | 0.04 |
TBI containing reduced intensity regimen | −2.0 | 0.10 | −1.9 | 0.17 |
Non TBI containing reduced intensity regimen | 0 | 0.97 | −1.0 | 0.22 |
Calcineurin inhibitor + Mycophenolate | −0.7 | 0.43 | −5.3 | <0.001 |
Calcineurin inhibitor + methotrexate | −1.0 | 0.19 | −4.7 | <0.001 |
Acute GVHD Grade 2-4 | 4.0 | <0.001 | 4.6 | <0.001 |
Viral infection | 0.1 | 0.82 | 0.6 | 0.34 |
Bacterial infection | 1.7 | 0.002 | 2.1 | 0.002 |
Fungal infection | 0 | 0.98 | 1.9 | 0.14 |
Baseline variables for the model (categorical variables):
Gender: Female; Race: Asian and others; Ethnicity: Non-Hispanic; Performance score: 90-100; HCT-CI:0-2; CMV status: Positive/Positive; Disease: MDS; Time from transplant to diagnosis: > 1 year; Period of transplant: 2012-2016;
Conditioning regimen: Non TBI containing myeloablative regimen; GVHD Prophylaxis: calcineurin inhibitor + others