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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Blood Cells Mol Dis. 2020 Sep 10;86:102504. doi: 10.1016/j.bcmd.2020.102504

Figure 2. Known metabolites associated with SCD complications and estimated glomerular filtration rate (eGFR) in GEN-MOD and OMG.

Figure 2.

We tested 129 metabolites against clinical complications by logistic regression (linear regression for quantitative eGFR). On the x-axis, we report odd ratios (effect sizes for eGFR) in metabolite standard deviation units, whereas the y-axis presents the observed analytical P-values. Red circles highlight metabolites with Pperm <0.05 calculated using 100,000 permutations. In total, we found 2 metabolites for painful crises, 2 metabolites with cholecystectomy, and 62 metabolites for eGFR.