Table 3.

Total Brain and Subcortical Volumes (% relative to ICV) Across Groups

ROI/ICV (%)	Non-User (N=46)	Primarily-K (K, N=39)	K+PolyS (N=41)	1-way ANCOVA p-value*				post hoc (corrected-p**)
				Age	Sex	Group	Linear trend	K vs. ND	K+PolyS vs. ND	K vs. K+PolyS
Total Grey Matter	38.7 ± 0.2	38.8 ± 0.2	38.5 ± 0.2	<0.001	<0.001	0.491	NS	---	---	---
Total White Matter	42.8 ± 0.1	42.9 ± 0.2	43.3 ± 0.1	0.140	0.157	0.009	0.004	0.857	0.011	0.05
L Caudate	0.338 ± 0.006	0.359 ± 0.006	0.355 ± 0.006	0.014	0.026	0.047	0.061	0.051	0.146	0.863
R Caudate	0.389 ± 0.004	0.400± 0.004	0.405 ± 0.004	0.073	0.140	0.035	0.011	0.206	0.030	0.698
L Putamen	0.428 ± 0.002	0.431 ± 0.002	0.43 ± 0.002	0.054	0.048	0.716	NS	---	---	---
R Putamen	0.453 ± 0.002	0.454 ± 0.002	0.454 ± 0.002	0.115	0.071	0.873	NS	---	---	---
L Globus Pallidus	0.12 ± 0.0 1	0.12 ± 0.0 1	0.12 ± 0.001	0.515	0.170	0.972	NS	---	---	---
R Globus Pallidus	0.117 ± 0.001	0.116 ± 0.001	0.115 ± 0.001	0.494	0.024	0.687	NS	---	---	---

^*P-values are from 1-way ANCOVA covaried for Age and Sex. P-values < 0.05 are bolded.

^**Corrected-p values are derived from the “adjusted p-values” from the Tukey tests.

L=left; R=right