Table 1.

P. falciparum growth inhibition by 1a-d, f, and indicated B- and C-ring analogs.

Entry	Compound	Dd2 strain P. falciparum Growth EC50 (nM)
1	1a	250 ± 70a, c
2	1b	>10,000a
3	1c	3,280 ± 990a, d
4	1d	1,170 ± 60a, e
5	1f	700 ± 90a, c
6	6a	>10,000
7	6b	>10,000b
8	6c	>10,000
9	6d	>10,000b
10	8a	190 ± 30a
11	12f	>10,000
12	12i	>10,000
13	16a	65% inhibition at 10 μM
14	(±)-20a	>10,000
15	24a	~8,000
16	25a	>10,000
17	26a	>10,000

^aReported previously.^10a

^bReported previously.^10b

^c100% rescued by 200 μM IPP @ 10 μM.

^d60% rescued by 200 μM IPP @ 10 μM.

^e50% rescued by 200 μM IPP @ 10 μM.

^f100% rescued by 200 μM IPP @ 2.5 μM.