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. Author manuscript; available in PMC: 2021 Nov 23.
Published in final edited form as: Dev Cell. 2020 Sep 22;55(4):432–449.e12. doi: 10.1016/j.devcel.2020.08.012

Figure 5: A genetic interaction between Megf8 and Mgrn1 causes heart defects and heterotaxy.

Figure 5:

(A) Summary of phenotypes observed in mouse embryos with the indicated genotypes (e13.5–14.5). Dex, dextrocardia; Lev, levocardia; LPI, left pulmonary isomerism; PDD, preaxial digit duplication; RPI, right pulmonary isomerism; SIT, situs inversus; SS, situs solitus. A detailed list of phenotypes observed in each embryo can be found in Tables S2, S3, and S4.

(B) Representative light microscopy and ECM images of the developing lungs and limbs of single (control) and double heterozygous embryos. The normal right lung has 4 lobes (1R, 2R, 3R and 4R) and the left lung has one lobe (1L). Asterisks (*) mark the duplicated preaxial digits.

(C) Representative necropsy images showing the position of the heart, symmetry of the liver, and location of the stomach in single (control) and double heterozygous embryos. Arrow (top row) denotes the direction of the cardiac apex. See also Tables S2, S3, and S4.