Table 1.

Secondary Screening Instruments

Cognitive Testing
• Learning and Memory: California Verbal Learning Task-II (CVLT-II)-63 sum of trials 1–5, immediate free recall, and long-delay free recall; Benson Figure Recall64
• Language: Boston Naming Test,65 Category Fluency,66 Lexical Fluency,66 Wide Range Achievement Test-4,66 Sentence Comprehension66
• Attention/Working Memory: CVLT-II trial 1,63 Digits Forward,67 Digits Backward,67 1-back,66 2-back66
• Executive Function: Trails B,67 Design Fluency,68 Stroop Interference66
• Psychomotor Speed: Trails A,67 Stroop Color Naming66
• Visuospatial: Benson Figure Copy,64 Visual Object and Space Perception,66 Comprehensive Affect Testing System Face Matching Test69
• Motor/Manual Dexterity: Grooved pegboard,70 Finger tapping71
• Mood/Affect: Geriatric Depression Scale (30 item)72
Functional Testing
• Neuropsychological Assessment Battery – Daily Living Module
Neurological Exam
• Eye movements, strength, sensation, coordination & extrapyramidal findings
• Targeted cognitive/behavioral review of symptoms, including date of first symptom to estimate duration of HAND
• Medical history including HIV variables (e.g., cART history & duration of cART and viral suppression, adherence, CD4 nadir), comorbidities
• Current medications and supplements
• Family history of neurological disorders
• Mood and psychiatric illnesses
• Drug and alcohol history
Geriatric Syndromes Assessment
• Whispered voice test
• Snellen eye chart
• Physical activity query
• Grip strength
• Short performance physical battery
• Timed gait
• Katz & Lawton Activities of Daily Living (ADL)73 and Instrumental Activities of Daily Living (IADL)74 scales
Clinical Labs
• Lymphocyte subset panel
• Plasma HIV RNA
• Complete blood count
• Hepatitis C antibody
• Alanine aminotransferase and Aspartate aminotransferase
• Creatinine
• Hemoglobin A1c
• Rapid plasma reagin
• Thyroid stimulating hormone
• Vitamin B12