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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Psychopharmacology (Berl). 2020 Sep 1;237(12):3703–3714. doi: 10.1007/s00213-020-05648-z

Table 1.

Potency (EC50) and efficacy (%Emax) of psychoactive benzofuran compounds to release [3H]MPP+ via DAT and NET, or [3H]5-HT via SERT, in rat brain synaptosomes.

Drug DAT release EC50 (nM) [%Emax] NET release EC50 (nM) [%Emax] SERT release EC50 (nM) [%Emax] DAT/SERT ratio DAT/NET ratio
MDA 106 ±7 [104%] 47 ±7 [91%] 162 ±28 [109%] 1.53 0.43
5-APB 31 ±3 [103%] 21 ±4 [103%] 19 ±2 [104%] 0.61 0.67
6-APB 10 ± 1 [101%] 14 ±2 [98%] 36 ±5 [100%] 3.60 1.40
MDMA 120 ±8 [101%] 90 ±13 [99%] 85 ±16 [104%] 0.71 0.75
5-MAPB 41 ±3 [103%] 24 ±3 [99%] 64 ±7 [103%] 1.56 0.58
6-MAPB 20 ±2 [106%] 14 ±2 [100%] 33 ±4 [106%] 1.65 0.70

Data are mean +/− SD for N=3 experiments performed in triplicate. Values in brackets are % of maximal release, as defined in Materials and Methods. DAT/SERT ratios are calculated as (DAT EC50)−1 /(SERT EC50)−1, where larger number indicates higher DAT selectivity. DAT/NET ratios are calculated as (DAT EC50)−1/(NET EC50)−1, where larger number indicates higher DAT selectivity.