Table 1.
Baseline characteristics on the date of 1st TRAC evaluation, stratified by 6MWT result tertile or EPTS category. Continuous variables are represented as median (25-75th percentile range). Categorical variables are represented as count (percentage). P-values refer to the test for trend across categories. Data is 100% complete unless stated otherwise.
| Baseline Characteristic | 6MWT Result in Meters | p | ||
|---|---|---|---|---|
| 0-329 | 334-425 | 426-681 | ||
| N=101 | N=102 | N=102 | ||
| Demographics and Follow-Up | ||||
| Age (year) | 61 (55-66) | 59 (51-64) | 50 (43-58) | <0.0001 |
| Sex (% female) | 59 (58%) | 53 (52%) | 30 (29%) | <0.0001 |
| Race/ethnicity (%) | ||||
| White | 16 (16%) | 20 (20%) | 12 (12%) | 0.6 |
| Black | 6 (6%) | 10 (10%) | 6 (6%) | |
| Hispanic, non-black | 52 (51%) | 35 (34%) | 56 (55%) | |
| Asian | 23 (23%) | 31 (30%) | 24 (24%) | |
| Other/Mixed | 4 (4%) | 6 (6%) | 4 (4%) | |
| Time from listing (years) | 6.2(4.5-8.7) | 5.7(2.8-7.6) | 6.4(4.1-7.7) | 0.2 |
| Follow-up timea (days) | 194 (35-449) | 411 (281-585) | 373 (175-476) | 0.007 |
| Comorbidities | ||||
| Dialysis vintage (year) | 8.1(5.1-9.6) | 6.8(4.6-8.4) | 6.8(4.5-8.3) | 0.05 |
| Diabetes mellitus (%) | 68 (67%) | 49 (48%) | 32 (31%) | <0.0001 |
| Hypertension (%) | 95 (94%) | 93 (92%) | 94 (92%) | 0.6 |
| Atherosclerotic diseaseb (%) | 53 (52%) | 34 (33%) | 22 (22%) | <0.0001 |
| Coronary artery disease*,c (%) | 22 (22%) | 21 (21%) | 16 (16%) | 0.2 |
| Peripheral artery diseased(%) | 35 (35%) | 11 (11%) | 5 (5%) | <0.0001 |
| Lower extremity amputation (%) | 13 (13%) | 2 (2%) | 4 (4%) | 0.01 |
| Ever smoked tobacco (%) | 35 (35%) | 33 (32%) | 44 (43%) | 0.2 |
| Measures of Physical Function | ||||
| Karnofsky score (at listing) | 80 (70-90) | 80 (80-90) | 80 (80-90) | 0.0007 |
| STS result (repetitions)* | 11 (0-14) | 17 (14-21) | 21 (19-26) | <0.0001 |
| Assistive walking device (%) | <0.0001 | |||
| None | 51 (50%) | 95 (93%) | 101 (99%) | |
| Cane/Walker | 45 (45%) | 6 (6%) | 1 (1%) | |
| Prosthesis | 1 (1%) | 1 (1%) | 0 (0%) | |
| Wheelchair | 4 (4%) | 0 (0%) | 0 (0%) | |
| Baseline Characteristic | STS Result in Number of Repetitions | p | ||
| 0-13 | 14-20 | 21-54 | ||
| N=103 | N=111 | N=90 | ||
| Demographics and Follow-Up | ||||
| Age (year) | 62 (55-67) | 54 (47-61) | 55 (44-63) | <0.001 |
| Sex (% female) | 58 (56%) | 49 (44%) | 35 (39%) | 0.01 |
| Race/ethnicity (%) | ||||
| White | 20 (19%) | 13 (12%) | 15 (17%) | 0.3 |
| Black | 13 (13%) | 4 (4%) | 5 (6%) | |
| Hispanic, non-black | 46 (45%) | 53 (48%) | 43 (48%) | |
| Asian | 18 (17%) | 36 (32%) | 24 (27%) | |
| Other/Mixed | 6 (6%) | 5 (5%) | 3 (3%) | |
| Time from listing (years) | 6.0(4.1-8.2) | 6.1(3.7-8.4) | 6.1(4.1-7.5) | 0.29 |
| Follow-up timea (days) | 281 (35-534) | 352 (148-492) | 499 (294-494) | 0.02 |
| Comorbidities | ||||
| Dialysis vintage (year) | 7.1(4.9-9.0) | 7.7(5.5-9.4) | 6.6(4.1-8.3) | 0.1 |
| Diabetes mellitus (%) | 62 (60%) | 50 (45%) | 37 (41%) | 0.007 |
| Hypertension (%) | 97 (94%) | 98 (88%) | 86 (96%) | 0.8 |
| Atherosclerotic diseaseb (%) | 54 (52%) | 36 (32%) | 19 (21%) | <0.0001 |
| Coronary artery disease*,c (%) | 25 (24%) | 22 (20%) | 12 (13%) | 0.06 |
| Peripheral artery diseased(%) | 26 (25%) | 17 (15%) | 8 (9%) | 0.002 |
| Lower extremity amputation (%) | 11 (11%) | 5 (5%) | 3 (3%) | 0.04 |
| Ever smoked tobacco (%) | 34 (33%) | 41 (37%) | 36 (40%) | 0.3 |
| Measures of Physical Function | ||||
| Karnofsky score (at listing) | 80 (70-90) | 80 (70-90) | 90 (80-90) | 0.006 |
| 6MWT result (meters) | 274 (137-362) | 396 (340-447) | 457 (413-499) | <0.0001 |
| Assistive walking device (%) | <0.0001 | |||
| None | 53 (51%) | 102 (92%) | 88 (98%) | |
| Cane/Walker | 45 (44%) | 9 (8%) | 2 (2%) | |
| Prosthesis | 1 (1%) | 0 (0%) | 0 (0%) | |
| Wheelchair | 4 (4%) | 0 (0%) | 0 (0%) | |
| Baseline Characteristic | EPTS Category | p | ||||
|---|---|---|---|---|---|---|
| 0-19 | 20-39 | 40-59 | 60-79 | 80-100 | ||
| N=32 | N=52 | N=39 | N=61 | N=121 | ||
| Demographics and Follow-Up | ||||||
| Age (year) | 35 (26-40) | 47 (44-52) | 56 (47-59) | 54 (51-64) | 64 (60-69) | <0.0001 |
| Sex (% female) | 15 (47%) | 26 (50%) | 17 (44%) | 28 (46%) | 56 (46%) | 0.8 |
| Race/ethnicity (%) | ||||||
| White | 3 (9%) | 9 (17%) | 8 (21%) | 8 (13%) | 20 (17%) | 0.5 |
| Black | 1 (3%) | 4 (8%) | 4 (10%) | 6 (10%) | 7 (6%) | |
| Hispanic, non-black | 20 (63%) | 31 (60%) | 15 (38%) | 27 (44%) | 50 (41%) | |
| Asian | 7 (22%) | 8 (15%) | 10 (26%) | 18 (30%) | 35 (29%) | |
| Other/Mixed | 1 (3%) | 0 | 2 (5%) | 2 (3%) | 9 (7%) | |
| Time from listing (years) | 5.3 (2.8-8.0) | 6.8 (3.9-9.0) | 6.1 (4.3-6.9) | 5.8 (3.3-7.8) | 6.2 (4.4-8.4) | 0.1 |
| Follow-up timea (days) | 310(163-451) | 400(146-568) | 470(392-612) | 339(209-472) | 273(76-486) | 0.06 |
| Comorbidities | ||||||
| Dialysis vintage (year) | 6.2 (2.6-8.1) | 8.2 (4.5-10.0) | 6.7 (5.8-8.3) | 6.7 (4.6-8.3) | 7.8 (6-9.6) | 0.009 |
| Diabetes mellitus (%) | 0 (0%) | 3 (6%) | 10 (26%) | 37 (61%) | 99 (82%) | <0.0001 |
| Hypertension (%) | 30 (94%) | 42 (81%) | 39 (100%) | 57 (93%) | 114 (94%) | 0.1 |
| Atherosclerotic diseaseb (%) | 2 (6%) | 10 (19%) | 10 (26%) | 21 (34%) | 66 (55%) | <0.0001 |
| Coronary artery disease*,c (%) | 0 (0%) | 5 (10%) | 8 (21%) | 11 (18%) | 35 (29%) | <0.0001 |
| Peripheral artery diseased(%) | 0 (0%) | 5 (10%) | 2 (5%) | 14 (23%) | 30 (25%) | <0.0001 |
| Lower extremity amputation (%) | 0 (0%) | 2 (4%) | 1 (3%) | 2 (3%) | 14 (12%) | 0.008 |
| Ever smoked tobacco (%) | 8 (25%) | 17 (33%) | 18 (46%) | 22 (36%) | 47 (39%) | 0.2 |
| Measures of Physical Function | ||||||
| Karnofsky score (at listing) | 90 (80-100) | 90 (80-90) | 90 (80-90) | 80 (70-90) | 80 (70-90) | 0.0002 |
| 6MWT result (meters) | 454 (390-457) | 444 (399-488) | 425 (388-473) | 367 (305-445) | 324 (238-400) | <0.0001 |
| STS result (repetitions)* | 21 (16-25) | 20 (15-25) | 20 (15-23) | 17 (12-20) | 14 (9-20) | <0.0001 |
| Assistive walking device (%) | 0.02 | |||||
| None | 30 (94%) | 45 (87%) | 35 (90%) | 45 (74%) | 92 (76%) | |
| Cane/Walker | 2 (6%) | 5 (10%) | 4 (10%) | 15 (25%) | 26 (21%) | |
| Prosthesis | 0 (0%) | 0 (0%) | 0 (%) | 0 (%) | 2 (2%) | |
| Wheelchair | 0 (0%) | 2 (4%) | 0 (0%) | 1 (2%) | 1 (1%) | |
*
Missing fewer than 1% of the data.
a
Follow-up time: Time between 1st TRAC visit (and ascertainment of all baseline characteristics) and date of censoring.
b
Atherosclerotic disease: A history of clinically significant coronary artery disease (see below), peripheral artery disease (see below), or cerebrovascular disease (ischemic cerebrovascular accident or revascularization).
c
Coronary artery disease: A history of acute coronary syndrome or coronary revascularization.
d
Peripheral artery disease: A history of revascularization, amputation, or clinical claudication with confirmed diagnosis.