Figure 1.

Scheme of genetically edited cell membrane-coated magnetic nanoparticles (gCM-MNs) elicit potent macrophage immune responses for cancer immunotherapy. A) Cell membranes were isolated from the genetically engineered cells that overexpressing SIRPα variants and then coated onto magnetic nanoparticles (MNs). B) Under external magnetic field, gCM-MNs efficiently accumulate in the tumor microenvironment, block the CD47-SIRPα ‘don’t eat me’ pathway, and repolarize tumor-associated macrophages (TAMs) towards M1 phenotype, promoting macrophage phagocytosis of cancer cells as well as boosting antitumor T-cell immunity.