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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Biochim Biophys Acta Gene Regul Mech. 2020 Sep 24;1863(11):194628. doi: 10.1016/j.bbagrm.2020.194628

Figure 6. Schematic showing miR-142–3p-mediated regulation of myeloid cell pathways related to cell migration, cell polarity, cytoskeletal homeostasis and phagocytosis.

Figure 6.

Macrophages or DC transfected with miR-142–3p mimics display impaired cellular functions compared to control mimic. miR-142–3p-mediated downregulation of multiple genes including vinculin, Dab2, Skap2 (novel validated targets), Vasp and LIMS1 can suppress cellular functions related to cell migration/motility, cell polarity, phagocytosis, and cytoskeletal rearrangement.