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. 2020 Nov 24;5:108. doi: 10.1038/s41541-020-00258-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a A principal component analysis of gene expression profiles (top 500 most variable genes) for the intramammary-immunized IMM cows at B7. b At 12 h post infection and c and at 40 h post infection; d a modular analysis at B7 shows the difference of upregulated biological functions between cured and not cured cows (p value above 10⁻⁴).