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. 2020 Nov 24;6:62. doi: 10.1038/s41523-020-00204-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A TMA cores from breast and colon cancer cases show preferential CX229 (cases #1 and #3) or preferential SP21 staining (cases #2 and #4). Algorithmic analysis for each TMA core shows COX2 positive signal (orange and red) compared to negatively stained tissue (blue). B Sequential sections of individual cases were stained for SP21 (red) and CX229 (blue), and evaluated for COX2 expression in far and adjacent normal, DCIS, and invasive breast cancer tissue (n = 9). SP21 shows highest expression in the DCIS lesions. Clone CX229 shows highest COX2 expression in normal far and adjacent breast epithelium, with decreased COX2 expression in invasive cancer (*P values: ≤ 0.05). Scale bar for all images is 100 µm.