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. 2020 Nov 24;10:20460. doi: 10.1038/s41598-020-77452-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of the electronic cigarette (ECIG) aerosol exposure set up for bronchial (bro-ALI) and alveolar (alv-ALI) mucosa models. A vaping regime mimicking one day of low intensity vaping was applied and consisted of repeated exposure [40 watts (W), 40 ml/puff, 3 s (s) puff duration, 30 s puff interval, 10 puffs/session, bro-ALI model: 6 sessions, alv-ALI model: 3 sessions, 1 h session interval] leading to a total of 60 puffs and 30 puffs for bro-ALI and alv-ALI, respectively. The authors sincerely acknowledge the assistance of Ann-Katrin Sjödén in preparing the figure.