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. 2020 Nov 24;10:20418. doi: 10.1038/s41598-020-76876-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of pathway analysis of IEI-EMF group compared to Controls. Plot was obtained by using MetaboAnalyst 4.0. “X axis” represents the impact of the identified metabolites on the indicated pathway. “Y axis” indicates the extent to which the designated pathway is enriched in the identified metabolites. Circle colors indicate pathway enrichment significance. Circle size indicates pathway impact. 1, Glycine, serine and Threonine metabolism; 2, Aminoacyl-tRNA biosynthesis; 3, Nitrogen metabolism; 4, Glutathione metabolism; 5, Purine metabolism; 6, Cyanoaminoacid metabolism; 7, Alanine, aspartate and glutamate metabolism and 8, d-glutamine and d-glutamate metabolism.