Table 3.

Examples of some aptamers directly conjugated with different drugs and targeted to specific diseased sites

Aptamer and its type	Drug	Target sites	References
DNA aptamer (P19)	MMAE	Anti-Pancreatic ductal adenocarcinoma	Yoo et al. (2017)
Long repetitive drug intercalating dsDNA	Doxorubicin	antitumor efficacy in leukemia mouse xenograft tumor model	Zhu et al. (2013)
NucA aptamers	MMAE and MMAF	Tf and EGF receptor binding on pancreatic cancer cell lines	Kratschmer and Levy (2018)
Nucleolin aptamer	PTX	Human ovarian cancer xenografted mouse model	Li et al. (2017)
DNA aptamer sgc8	Doxorubicin	protein tyrosine kinase 7 overexpressed on many types of cancers	Meng et al. (2010)
DNA sgc8 aptamer	N-heterocyclic carbene–gold complexes	CCRF-CEM leukemia cells	Niu et al. (2016)
DNA strand P19	5-fluorouracil	pancreatic cancer cell line PANC-l cells	Kruspe and Hahn (2014)
dsDNA/dsRNA sgc8, AS1411	Anthracycline drugs (Dox, Epirubicin, Daunorubicin), cisplatin	Tumor growth, leukemia, liver cancer xenograft,	Zhu et al. (2012a)
RNA aptamer A10	Doxorubicin	PMSA targeting, anticancer drug delivery against cancer and leukemia xenograft model	Bagalkot et al. (2006)
Sgc8 + sgd5a	Anticancer drug delivery	Cancer detection	Zhu et al. (2012b)
Phosphoramidite linker with sgc8	5-flurorouracil	Colorectal and pancreatic cancer treatment	Wang et al. (2014a, b, c, d)

MMAE monomethyl auristatin E, MMAF monomethyl auristatin F, Tf transferrin, EGF epidermal growth factor, PTX paclitaxel