Table 5.
DNA aptamers and their role in different diseases, targeted against specific ligands
| Disease | DNA aptamer name | Length (mer) | Ligand/target | References |
|---|---|---|---|---|
| Infectious diseases | 2008a | 35 | Plasmodium falciparum LDH (PfLDH) | Cheung et al. (2013) |
| Sequence (2) | 74 | HA protein (H5N1) | Wang et al. (2013) | |
| 4C6 | 45 | Truncated murine prion protein (H-MoPrP90-231) | Xiao et al. (2012) | |
| LmWC-25R and LmHSP-7b/11R | 36 | Leishmania promastigote and hydrophilic surface protein (HSP) | Bruno et al. (2014) | |
| Cancer | 32 | 30 | Glioblastoma multiforme cells (U87Δ) epidermal growth factor receptor variant III (EGFRvIII) | Tan et al. (2013) |
| Aptamer BC15 | 111 | Heterogenous nuclear ribonucleoprotein A1 (hnRNP A1) | Li et al. (2009) | |
| DNA aptamer HB5 | 19 | Her 2 (human EGFR 2) | Liu et al. (2012) | |
| DNA aptamer A and C | 32 | TTF1 (a member of the NK homeodomain transcription factor) | Murphy et al. (2003) | |
| SYL3 DNA aptamer | 38 | EpCAM (epithelial cell adhesion molecule) | Song et al. (2013) | |
| MUC1 DNA aptamer | 33 | MUC1 peptide | Ferreira et al. (2006) | |
| AGC 03 | 40 | Gastric cancer cells (HGC-27) | Zhang et al. (2014) | |
| C-2 | 50 | Liver cancer cells (HepG2) | Ninomiya et al. (2013) | |
| Cy-apt20 | 52 | Gastric carcinoma cells (AGS) | Cao et al. (2014) | |
| JHIT2 | 25 | Liver cancer cells (HepG2) | Xu et al. (2015) | |
| GMB128 | 45 | Glioblastoma cells (U118-MG) | Li et al. (2014a, b) | |
| GMT3 | 42 | Glioblastoma multiforme cells (A172) | Bayrac et al. (2011) | |
| LXL-1 | 45 | Metastatic breast cancer cells (MDA-MB-231) | Urata et al. (1992) | |
| SYL3-C | 40 | Solid cancer | Song et al. (2013) | |
| Vea5 (SL2-B) | 30 | Cancer cells biomarker: VEGF165) | Kaur and Yung (2012); Hasegawa et al. (2008) | |
| Wy-5a | 45 | Prostate cancer cells (PC-3, metastatic) | Wang et al. (2014a, b, c, d) | |
| XL-33 | 45 | Metastatic colon cancer cells (SW620) | Li et al. (2015) | |
| XQ-2d | 42 | Pancreatic ductal adenocarcinoma (PDAC) cells (PL45) | Wu et al. (2015) | |
| y119 | 40 | Cholangiocarcinoma cells (QBC-939) | Wan et al. (2015) | |
| Cardiovascular disease | Hcy8 | 60 | L-homocysteine | McKeague et al. (2013) |
| Myo040-7-27 | 40 | Myoglobin | Wang et al. (2014a, b, c, d) | |
| Food borne disease | DNA aptamer | 20 | OmpC | Han et al. (2013) |