TABLE 1.

Analysis of neurite morphology of adult newborn neurons in human A53T α-syn transgenic animals (A53T-tg) vs. non-transgenic controls (non-tg), and in C57Bl/6 animals (cell-intrinsic overexpression of A53T α-syn GFP vs. GFP only).

	Non-tg	A53T-tg	P	CAG-GFP	CAG-A53T-GFP	P
Animals per genotype	4	4		4	4
Age at injection (months)	4	4		1.5	1.5
Dendritic length (μm)	462 ± 211	461 ± 189	0.99	631 ± 175	637 ± 214	0.92
Branching points (per cell)	5.25 ± 1.3	5.17 ± 2.0	0.92	6.54 ± 2.19	7.08 ± 1.82	0.35
Spine density (per μm)	1.40 ± 0.29	1.07 ± 0.28	0.0005	1.87 ± 0.59	1.29 ± 0.38	0.004
Density of mushroom spines (per μm)	0.077 ± 0.042	0.040 ± 0.026	0.0008	0.047 ± 0.018	0.035 ± 0.020	0.15
Density of SERT-positive fibers (per μm3)	0.019 ± 0.0016	0.018 ± 0.0023	0.43

Numbers are given as mean ± SD and respective P-values.