TABLE 1.
Antimicrobial susceptibility of planktonic (MIC) and biofilm (MBEC) Staphylococcus aureus strains determined by conventional broth macrodilution assay and sonication/colony-counting.
|
Antibiotic |
VAN |
DAP |
FOF |
GEN |
RIF |
|||||
| MRSA strains | MIC | MBEC | MIC | MBEC | MIC | MBEC | MIC | MBEC | MIC | MBEC |
| MRSA ATCC 43300 | 1 | >1,024 | 0.5 | 128 | 8 | >1,024 | 64(R) | >1,024 | 0.008 | 256 |
| MRSA1 | 1 | >1,024 | 0.5 | 64 | 4 | >1,024 | 0.5 | 256 | 32(R) | >1,024 |
| MRSA2 | 2 | >1,024 | 1 | 128 | 4 | >1,024 | 0.5 | 512 | 1(R) | >1,024 |
| MRSA3 | 1 | >1,024 | 0.5 | 64 | 128(R) | >1,024 | 0.5 | 512 | 32(R) | >1,024 |
| MRSA4 | 1 | >1,024 | 1 | 128 | 4 | >1,024 | 0.5 | >1,024 | 4(R) | >1,024 |
|
Antibiotic |
FLU |
CFZ |
FOF |
GEN |
RIF |
|||||
| MSSA strains | MIC | MBEC | MIC | MBEC | MIC | MBEC | MIC | MBEC | MIC | MBEC |
| MSSA ATCC 29213 | 0.5 | >1,024 | 0.5 | >1,024 | 4 | >1,024 | 1 | 512 | 0.016 | 256 |
| MSSA1 | 0.25 | 1,024 | 0.25 | >1,024 | 16 | >1,024 | 0.5 | 512 | 1(R) | >1,024 |
| MSSA2 | 0.5 | 1,024 | 0.5 | >1,024 | 4 | >1,024 | 0.5 | 512 | 32(R) | >1,024 |
| MSSA3 | 0.5 | 1,024 | 0.5 | >1,024 | 8 | >1,024 | 0.5 | >1,024 | 32(R) | >1,024 |
| MSSA4 | 0.25 | >1,024 | 0.25 | >1,024 | 8 | >1,024 | 0.5 | >1,024 | 1(R) | >1,024 |
| MSSA5 | 0.5 | 512 | 0.5 | >1,024 | 16 | >1,024 | 8(R) | >1,024 | 2(R) | >1,024 |
| MSSA6 | 0.5 | >1,024 | 0.25 | >1,024 | 4 | >1,024 | 0.5 | 1,024 | 1(R) | >1,024 |
MIC and MBEC concentration values are expressed in μg/ml. VAN, vancomycin; DAP, daptomycin; FOF, fosfomycin; GEN, gentamicin; RIF, rifampin; FLU, flucloxacillin; CFZ, cefazolin; R, resistance against the antibiotic according to EUCAST.