Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 11;8:548283. doi: 10.3389/fcell.2020.548283

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Jeon, Kwon, Jo, Lee, Kim and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic overview of α-synuclein physiology and pathology. (A) Pathological conformation change of α-syn. α-syn composed of N-terminal, NAC, and C-terminal. Originally, α-syn exist as native or misfolded monomeric state. Monomeric α-syn can aggregate into cytotoxic oligomer or fibrillar α-syn. Aggregated α-syn forms Lewy body and it can propagate into other cells. (B) α-Synucleinopathies in neurodegenerative diseases. Aggregated α-syn is associated many neurodegenerative diseases such as Parkinson’s disease, Dementia with Lewy Body, Pure Autonomic Failure and Multiple System Atrophy. PD, DLB and PAF belong to Lewy body disease.