TABLE 1.

Role of mitophagy regulators in tumorigenesis.

Mitophagy regulator	Tumor type	Function in cancer	Mechanisms	References
BNIP3	Breast tumor	Tumor suppressor	Inhibits glycolysis and angiogenesis	Chourasia et al., 2015
BNIP3	Pancreatic cancer	Tumor suppressor	Promotes hypoxia-induced cell death	Okami et al., 2004
BNIP3	Colorectal cancer	Tumor suppressor	Promotes hypoxia-induced cell death	Murai et al., 2005; Bacon et al., 2007
BNIP3	Gastric cancer	Tumor suppressor	Promotes hypoxia-induced cell death	Murai et al., 2005
BNIP3L	Pancreatic ductal adenocarcinoma	Tumor promoter	Increases glucose metabolism and antioxidant capacity	Humpton et al., 2019
Ceramide	Head and neck squamous cell carcinoma, acute myeloid leukemia cells	Tumor suppressor	Promotes cell death	Sentelle et al., 2012; Dany et al., 2016
FUNDC1	Hepatocellular carcinoma	Tumor suppressor	Inhibits inflammation	Li et al., 2019a
FUNDC1	Laryngeal cancer	Tumor promoter	Promotes cell proliferation and survival	Hui et al., 2019
FUNDC1	Cervical cancer	Tumor suppressor	Promotes apoptosis	Hou et al., 2017
PHB2	Cervical/non-small cell lung/colorectal cancer cells	Tumor suppressor	Promotes activation of PINK1-PRKN pathway	Yan et al., 2020
PHB2	Non-small cell lung carcinoma	Tumor promoter	Promotes cell proliferation and migration	Zhang et al., 2020
PINK1	Pancreatic ductal adenocarcinoma	Tumor suppressor	Inhibits inflammation and antitumor immunity	Li et al., 2018
PRKN	Pancreatic ductal adenocarcinoma	Tumor suppressor	Inhibits inflammation and antitumor immunity	Li et al., 2018; Yin et al., 2018
PRKN	Colon cancer	Tumor suppressor	Inhibits cell proliferation	Poulogiannis et al., 2010