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. 2020 Nov 11;11:592553. doi: 10.3389/fimmu.2020.592553

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Copyright © 2020 Binder, Sellberg, Cvetkovski, Berglund and Berglund

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD69 expression in pure T cell culture. Untouched T cells were purified using negative magnetic-activated cell sorting and kept in autologous culture for up to 7 days. Data displayed as mean percentage of CD69+ T cells +SD (N = 4). Data were analyzed using two-way ANOVA followed by Dunnett’s multiple comparison test (*p < 0.05, **p < 0.01). Siplizumab significantly reduced CD69 expression after 7 days of autologous culture (p = 0.0260), but not on previous time points. In contrast, Alemtuzumab significantly elevated CD69+ T cells after 5 (p = 0.0328) and 7 (p = 0.0057) days of autologous culture. rATG induced a significant increase in CD69 expression on T cells after 3 (p = 0.0232), 5 (p = 0.0052), and 7 (p = 0.0327) days.