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Schematic representation of hypoxia inducible factor-1α (HIF-1α) binding to the WNT7A promoter. Under normoxia, HIF-1α is hydroxylated by the active prolyl-hydroxylases (PHDs) and sent to proteasomal degradation. Under hypoxia or upon PHDs inhibition, HIF-1α cannot be hydroxylated, and it translocates to the cell nucleus, where it forms a transcriptional complex with its α-subunit and CBP/p300, and binds to specific HRE sequences on the WNT7A promoter region.
