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. 2020 Nov 11;10:592609. doi: 10.3389/fonc.2020.592609

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Copyright © 2020 Matull, Livingstone, Wetter, Zimmer, Zaremba, Lahner, Schadendorf and Ugurel

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune-related thyroiditis. (A) Time course of serum parameters reflecting the thyreoiditis after the application of ipilimumab plus nivolumab on 28.05.2018. Dotted lines represent the timepoint of initiation/discontinuation of thiamazole. TSH, thyroid stimulating hormone; fT4, free thyroxine; LLN, lower limit of normal; ULN, upper limit of normal. (B) Ultrasound showing hypoechoic, heterogeneous and hypervascular thyroid gland. (C) Tc99m scintigraphy showing proportional, slightly elevated tracer uptake (2.6%) throughout the thyroid gland.