Table 6.
Multivariate survival analysis of patients with colorectal cancer after including mpN stage in the training and validation cohorts.
| Prognosis factors | Training cohort | Validation cohort | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | *P value | HR | 95% CI | P value* | |
| Sex | 1.146 | 1.146 (1.044–1.258) | 0.004 | 1.145 | 1.145 (0.998–1.315) | 0.054 |
| Age, year | 1.531 | 1.531 (1.393–1.683) | <0.001 | 1.760 | 1.760 (1.527–2.029) | <0.001 |
| Size, cm | 1.076 | 1.076 (0.990–1.169) | 0.085 | – | – | – |
| Histological grade | 1.182 | 1.182 (1.110–1.259) | <0.001 | 1.091 | 1.091 (0.990–1.203) | 0.078 |
| pT stage | 1.572 | 1.572 (1.485–1.664) | <0.001 | 1.571 | 1.571 (1.444 - 1.709) | <0.001 |
| TD status | 0.853 | 0.853 (0.721–1.009) | 0.064 | 1.173 | 1.173 (0.931–1.477) | 0.176 |
| Retrieved LNs | 0.553 | 0.553 (0.485–0.630) | <0.001 | 0.669 | 0.669 (0.550–0.815) | <0.001 |
| pN stage | 0.994 | 0.994 (0.920–1.073) | 0.872 | 1.040 | 1.040 (0.934–1.158) | 0.474 |
| mpN stage | 1.416 | 1.416 (1.271–1.578) | <0.001 | 1.204 | 1.204 (1.038–1.397) | 0.014 |
CI, confidence interval; HR, hazard ratios; LNs: lymph nodes, mpN, modified pathological N; OS, overall survival; pN, pathological N.
*P value based on multivariate Cox proportional hazard models.