Table 3.

Pooled risk estimates for SNPs TNF-α −1031 T/C, −863 C/A, −857 C/T, −308 G/A, and − 238 G/A with HCC risk

SNP TNF-α	n	OR (95% CI)	p value for Z test	I2 for heterogenity	p value for heterogenity
−1031 T/C
C vs T	3	1.06 [0.89–1.26]	0.52	0.77	0
CC + TC vs TT	5	1.04 [0.86–1.27]	0.69	0.97	0
CC vs TT	3	1.39 [0.88–2.18]	0.15	0.99	0
CC vs TC + TT	3	1.41 [0.91–2.21]	0.13	1	0
TC vs TT	3	0.96 [0.77–1.19]	0.70	0.64	0
−863 C/A
A vs C	7	1.31 [1.03–1.67]	0.03*	0.007	66
AA+CA vs CC	8	1.19 [1.03–1.36]	0.02*	0.35	10
AA vs CC	7	1.43 [0.98–2.10]	0.07	0.50	0
AA vs CA + CC	7	1.28 [0.89–1.86]	0.19	0.84	0
CA vs CC	7	1.41 [1.00–1.99]	0.05	0.0007	74
−857 C/T
T vs C	4	1.16 [0.94–1.43]	0.17	0.45	0
TT + CT vs CC	5	1.31 [1.06–1.62]	0.01*	0.24	27
TT vs CC	4	0.75 [0.42–1.36]	0.35	0.87	0
TT vs CT + CC	4	0.77 [0.44–1.35]	0.36	0.77	0
CT vs CC	4	1.02 [0.77–1.34]	0.89	0.54	0
−308 G/A
A vs G	17	1.98 [1.62–2.42]	< 0.001*	0.03	44
AA+GA vs GG	19	1.95 [1.53–2.49]	< 0.001*	0.003	54
AA vs GG	13	3.14 [2.06–4.79]	< 0.001*	0.69	0
AA vs GA + GG	13	2.52 [1.69–3.76]	< 0.001*	0.81	0
GA vs GG	17	2.07 [1.60–2.68]	< 0.001*	0.006	52
−238 G/A
A vs G	8	1.50 [1.16–1.94]	0.002*	0.07	46
AA+GA vs GG	9	1.39 [0.87–2.24]	0.17	0.03	52
AA vs GG	5	3.87 [1.32–11.34]	0.01*	0.70	0
AA vs GA + GG	8	2.67 [1.17–6.10]	0.02*	0.87	0
GA vs GG	8	1.28 [0.72–2.28]	0.39	0.01	61

Note: *Significant p < 0.05