Table 1.

Correlation between the expression of PD-1, PD-L1, CD8, and CD68 and clinicopathological features

Characteristics	PD-1+			PD-L1+			CD8+			CD68+
	Low	High	P	Low	High	P	Low	High	P	Low	High	P
Age, years
< 60	41	132	0.965	124	49	0.120	54	119	0.646	100	73	0.551
≥ 60	35	114		118	31		43	106		91	58
Gender
Female	36	92	0.121	110	18	0.000	49	79	0.010	87	41	0.010
Male	40	154		132	62		48	146		104	90
HBsAg
Negative	55	144	0.030	153	46	0.361	67	132	0.078	125	74	0.104
Positive	21	102		89	34		30	93		66	57
Cirrhosis
No	58	178	0.495	181	55	0.290	72	164	0.803	142	94	0.606
Yes	18	68		61	25		25	61		49	37
CA19-9
Low (≤ 37)	28	135	0.006	128	35	0.156	39	124	0.014	96	67	0.876
High (> 37)	48	111		114	45		58	101		95	64
Child-Pugh
A	75	236	0.250	236	75	0.107	97	214	0.027	185	126	0.743
B	1	10		6	5		0	11		6	5
Tumor size (cm)
≤ 5	25	120	0.015	107	38	0.609	33	112	0.009	73	72	0.003
> 5	51	126		135	42		64	113		118	59
Tumor number
Single	57	187	0.857	188	56	0.164	72	172	0.670	154	90	0.014
Multiple	19	59		54	24		25	53		37	41
LN invasion
No	61	205	0.537	208	58	0.006	81	185	0.781	157	109	0.815
Yes	15	41		34	22		16	40		34	22
TNM stage
I	55	192	0.306	193	54	0.025	74	173	0.907	144	103	0.500
II–III	21	54		49	26		23	52		47	28
MVI
No	63	213	0.422	208	68	0.833	83	193	0.960	164	112	0.926
Yes	13	33		34	12		14	32		27	19

Chi-square test and Fisher’s exact test were performed

HBsAg hepatitis B surface antigen, CA19-9 carbohydrate antigen 19-9, LN lymph node, TNM tumor-nodes-metastasis, MVI microvascular invasion