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. 2020 Nov 23;10:134. doi: 10.1186/s13578-020-00497-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — SDF-1α induces different interaction patterns between Gβ₁ and GRK depending on the receptor. a Each of the chemokine receptors (CXCR4/CXCR7) was expressed in HEK293 cells together with Gβ₁ tagged with SmBit at the N-terminal and GRK2/GRK5 tagged with LgBit at the C terminal. Luciferase activities induced by SDF-1α or not (Veh.) were then measured. b Cells expressing CXCR4/CXCR7 tagged with LgBiT at the C-terminal and Gβ₁-SmBiT were treated with SDF-1α or not (Veh.), and then luminescence was measured. c Cells expressing CXCR4/CXCR7 tagged with LgBiT at the C-terminal and GRK2-SmBiT were treated with SDF-1α or not (Veh.), and then luminescence was measured. Results are the average of three independent experiments. Values are presented as the mean ± SD