TABLE 3.

Two-sample MR analysis.

Trait	IVW effect size	IVW 95% CI	IVW P-value	Egger intercept	Egger intercept P-value	MR-PRESSO global test P-value
BMI	1.80	1.28–2.54	0.001	0.013	0.129	0.557
WC	1.25	0.86–1.79	0.238	0.004	0.772	0.817
SBP	0.79	0.52–1.20	0.278	0.00003	0.966	0.674
Fasting glucose	0.78	0.51–1.19	0.253	−0.019	0.111	0.791
HbA1c	0.26	0.01–8.47	0.446	0.022	0.024	0.813
LDL cholesterol	1.20	1.06–1.37	0.006	0.001	0.899	0.741
HDL cholesterol	1.03	0.84–1.25	0.803	−0.01	0.144	0.875
Triglycerides	1.10	0.79–1.53	0.578	0.002	0.876	0.939

Effect sizes represent odds ratio for every 1 standard deviation increment in exposure trait. BMI, body mass index; WC, waist circumference; SBP, systolic blood pressure, HbA1c, glycated hemoglobin; LDL, low-density lipoprotein; HDL, high-density lipoprotein; IVW, inverse variance weighted; CI, confidence interval; MR, Mendelian randomization.