Table 1.
Characteristics of laboratory animals before the start of the experiment
| Total (n = 12) | FCV (n = 6) | PCV (n = 6) | MD with 95% CIa | p valueb | ||
|---|---|---|---|---|---|---|
| Demographic data | ||||||
| Weight | kg | 37.8 (33.8–43.3) | 36.2 (32.9–38.7) | 40.5 (36.6–44.8) | − 4.1 (− 11.6 to 2.3) | 0.240 |
| Size | m | 1.08 (1.07–1.10) | 1.08 (1.06–1.10) | 1.08 (1.07–1.14) | −0.03 (− 0.09 to 0.03) | 0.511 |
| Gender | female | 7/12 (58.3%) | 4/6 (66.7%) | 3/6 (50%) | 0.53 (0.03 to 8.30) | 1 |
| Monitoring data | ||||||
| HR | /min | 89.0 (81.0–95.5) | 91.0 (84.0–94.3) | 85.0 (76.8–94.8) | 3.9 (−8.0 to 20.0) | 0.521 |
| MAP | mm Hg | 65.5 (63.0–72.0) | 73.0 (66.5–75.75) | 63.0 (63.0–65.3) | 8.0 (−4.0 to 15.0) | 0.106 |
| MPAP | mm Hg | 22.0 (20.0–23.3) | 21.0 (20.3–24.8) | 23.0 (20.8–23.0) | −0.5 (−4.0 to 8.0) | 1 |
| CVP | mm Hg | 10.0 (8.0–13.0) | 9.0 (8.0–10.0) | 13.0 (10.8–13.0) | −3.0 (−6.0 to 6.0) | 0.220 |
| CI | l/min/m2 | 6.1 (5.7–6.6) | 6.0 (5.6–6.4) | 6.2 (5.9–7.5) | −0.4 (− 2.2 to 0.7) | 0.485 |
| PCWP | mmHg | 11.0 (9.0–13.0) | 10.0 (6.0–11.0) | 12.5 (11.3–13.0) | −3.0 (−8.0 to 2.0) | 0.195 |
| VT | ml/kg | 7.1 (7.1–7.5) | 7.2 (7.1–7.7) | 7.1 (7.0–7.3) | 0.1 (−0.3 to 0.9) | 0.191 |
| RR | /min | 35.0 (33.8–37.3) | 34.0 (31.0–36.3) | 36..0 (34.5–37.5) | −2.0 (−8.0 to 2.0) | 0.332 |
| MV | l/min | 9.5 (9.0–11.6) | 9.1 (8.9–9.4) | 11.6 (10.1–11.8) | −2.4 (−4.3 to −0.1) | 0.041* |
| Ppeak | cm H2O | 19.5 (18.0–22.5) | 18.5 (18.0–19.8) | 23.0 (19.0–27.0) | −4.0 (−10.0 to 1.0) | 0.195 |
| ΔP | cm H2O | 14.5 (13.0–17.5) | 13.5 (13.0–14.8) | 18.0 (14.0–22.0) | −4.0 (−10.0 to 1.0) | 0.195 |
| Pes | cm H2O | 12.0 (12.0–15.0) | 12.0 (12.0–15.0) | 12.5 (12.0–14.5) | 0.0 (− 4.0 to 3.0) | 0.924 |
| paCO2 | Torr | 41.1 (39.3–43.3) | 40.4 (39.0–42.8) | 41.8 (40.0–42.9) | −0.9 (−4.6 to 2.5) | 0.699 |
| kPa | 5.47 (5.24–5.77) | 5.38 (5.20–5.70) | 5.57 (5.33–57.20) | −0.12 (− 0.61 to 0.33) | ||
| paO2 | Torr | 120.5 (97.8–127.3) | 113.5 (99.8–123.5) | 123.0 (95.8–130.8) | −4.5 (−30.0 to 34.0) | 0.818 |
| kPa | 16.07 (13.03–16.97) | 15.13 (13.30–16.47) | 16.40 (12.77–17.43) | −0.60 (−4.00 to 4.53) | ||
CI cardiac index, CVP central venous pressure, FCV flow-controlled ventilation, HR heart rate, MAP mean arterial pressure, MD mean difference, MPAP mean pulmonary arterial pressure, MV respiratory minute volume, paCO2 arterial partial pressure of carbon dioxide, paO2 arterial partial pressure of oxygen, PCV pressure-controlled ventilation, PCWP pulmonary capillary wedge pressure, Pes esophageal pressure, Ppeak peak pressure, RR respiratory rate, VT tidal volume, ΔP driving pressure (difference between positive end-expiratory pressure and peak pressure);
Binary data are presented as no./total no. (%), continuous data as medians (25th to 75th percentile)
aOdds ratios for binary variables and estimated median difference for continuous variables
bAssessed by Fisher’s exact test for categorical variables and Wilcoxon rank sum test for continuous variables