Table 2.
Course of parameters over 10 h with estimated differences between groups
| FCV meana | PCV meana | MD with 95% CIa | p valuea | ||
| HR | /min | 84.0 | 79.6 | 4.4 (−5.0 to 13.8) | 0.378 |
| MAP | mmHg | 70.1 | 65.1 | 5.0 (−0.3 to 10.4) | 0.093 |
| MPAP | mmHg | 21.8 | 22.8 | −1.0 (−4.8 to 2.8) | 0.615 |
| CVP | mmHg | 9.5 | 12.1 | −2.6 (−6.1 to 0.9) | 0.177 |
| CI | l/min/m2 | 5.4 | 5.7 | −0.3 (−1.0 to 0.4) | 0.410 |
| PCWP | mmHg | 9.5 | 12.6 | −3.1 (−6.5 to 0.3) | 0.108 |
| PVRI | dyn s/cm5/m2 | 327.2 | 260.2 | 67.0 (20.9 to 113.1) | 0.017* |
| SVRI | dyn s/cm5/m2 | 1646.1 | 1353.0 | 293.1 (51.4 to 534.7) | 0.039* |
| Pes | cm H2O | 12.3 | 13.9 | −1.6 (−3.7 to 0.5) | 0.178 |
| VT | ml/kg | 8.2 | 7.6 | 0.7 (0.2 to 1.2) | 0.025* |
| RR | /min | 20.1 | 41.5 | −21.3 (−22.8 to −19.9) | < 0.001*** |
| Ppeak | cm H2O | 16.3 | 17.5 | −1.2 (−3.5 to 1.2) | 0.350 |
| ΔP | cm H2O | 13.0 | 12.5 | 0.6 (−1.7 to 2.8) | 0.638 |
| MP | J/min | 5.8 | 22.0 | −16.2 (−21.1 to − 11.4) | < 0.001*** |
| MV | l/min | 6.0 | 12.7 | −6.8 (−8.2 to −5.4) | < 0.001*** |
| paCO2 | Torr | 40.1 | 44.9 | −4.7 (−7.4 to −2.0) | 0.006** |
| kPa | 5.35 | 5.98 | −0.63 (−0.99 to −0.27) | ||
| paO2 | Torr | 119.8 | 96.6 | 23.2 (9.0 to 37.5) | 0.010* |
| kPa | 15.97 | 12.87 | 3.10 (1.19 to 5.00) | ||
| PEEP | FCVb | PCVb | p valuec | ||
| 5 | cm H2O | 1/6 (17%) | 6/6 (100%) | 0.002** | |
| 4 | cm H2O | 0/6 (0%) | 0/6 (0%) | – | |
| 3 | cm H2O | 5/6 (83%) | 0/6 (0%) | – | |
CI cardiac index, CVP central venous pressure, FCV flow-controlled ventilation, HR heart rate, MAP mean arterial pressure, MD mean difference, MP mechanical power, MPAP mean pulmonary arterial pressure, MV respiratory minute volume, paCO2 arterial partial pressure of carbon dioxide, paO2 arterial partial pressure of oxygen, PCV pressure-controlled ventilation, PCWP pulmonary capillary wedge pressure, PEEP positive end-expiratory pressure, Pes esophageal pressure, Ppeak peak pressure, PVRI pulmonary vascular resistance index, RR respiratory rate, SVRI systemic vascular resistance index, VT tidal volume, ΔP driving pressure (difference between positive end-expiratory pressure and peak pressure)
aEstimated mean and median difference with CI for continuous variables retrieved from linear mixed-effects model
bBinary data are presented as no./total no. (%)
cAssessed by Fisher’s exact test