Table 2.
COVID-19 case: Five clusters of enriched Maximum Common Substructures which were retrieved from DrugBank and the CAS data set
| Cluster number | Maximum Common Substructure | SMARTS String | # Hits | Targets |
|---|---|---|---|---|
| 1 |
|
[#6](:[#7]:[#6]:[#7]-,:[#6]-,:[#6]-[#6]-[#6]):[#6] | 53 | PPIA_HUMAN |
|
[#6](-,:[#6]-,:[#6]-[#6]-[#6] = [#6]-[#6])-,:[#6]-,:[#6] | 5 | PPIA_HUMAN | |
|
|
[#6]:,-[#6]-,:[#7]-,:[#6]:,-[#6]:,-[#6]:,-[#6]:[#6]:[#6] | 1 | PPIA_HUMAN | |
| 2 |
|
[#6]1:[#7]:[#6]:[#7]:[#6]2:[#6]:1:[#7]:[#6]:[#7]:2-[#6]1-[#8]-[#6]-[#6]-[#6]-1 | 36 | R1AB_SARS2 |
|
[#7]1:[#6]:[#7]:[#6]2:[#6]:1:[#7]:[#6]:[#7]:[#6]:2 | 11 | PPIA_HUMAN | |
|
[#6]1:[#7]:[#6]:[#7](-[#6]2-[#8]-[#6]-[#6]-[#6]-2):[#7]:1 | 3 | PPIA_HUMAN | |
|
[#6]1:[#7]:[#6]:[#7]:[#6](:[#6]:1):[#7](:[#6])-[#6]1-[#8]-[#6]-[#6]-[#6]-1 | 2 | PPIA_HUMAN | |
|
[#6]1(-[#6]2:[#6]:[#6]:[#6]3:[#6]:[#7]:[#6]:[#7]:[#7]:2:3)-[#8]-[#6]-[#6]-[#6]-1 | 1 | R1AB_SARS2 | |
| 3 |
|
[#7]1-[#6]-[#6]-[#7]-[#6]-[#6]-1 | 8 | R1AB_SARS2 |
|
[#6]-:[#6]-:[#6](-[#6](= [#8])-[#7]-[#6](:-[#6]:-[#6]):-[#6]:-[#6])-:[#6]-:[#6] | 4 | R1AB_SARS2 | |
|
[#6]1:[#6]:[#6]:[#6]2:[#6](:[#6]:1)-[#8]-[#6]-[#8]-2 | 3 | R1AB_SARS2 | |
|
[#6]1:[#7]:[#6]:[#6]:[#6]:[#6]:1 | 3 | PPIA_HUMAN | |
|
[#6](-[#6]-[#6]1-[#6]-[#6]-[#7]-[#6]-1 = [#8])-[#7]-[#6](= [#8])-[#6] | 2 | R1A_SARS, R1AB_SARS | |
|
[#6](-[#6]-[#6]1-[#6]-[#6]-[#7]-[#6]-1 = [#8])-[#7]-[#6](= [#8])-[#6]-[#6]-[#6]1:[#6]:[#6]:[#6]:[#6]:[#6]:1 | 2 | R1A_SARS, R1AB_SARS | |
| 4 |
|
[#6](-[#7]-[#6](= [#8])-[#6]1-[#6](-[#6]-[#6]-[#7]-1-[#6](= [#8])-[#6]-[#7]-[#6] = [#8])-[#6])-[#6]-[#6](= [#8])-[#7]-[#6]1-[#6]-[#6]-1 | 1 | R1AB_SARS2 |
|
[#6](-[#7]-[#6](= [#8])-[#6]1-[#6]2-[#6]-[#6]-[#6]-[#6]-2-[#6]-[#7]-1)-[#6]-[#6](= [#8])-[#7]-[#6]1-[#6]-[#6]-1 | 1 | R1AB_SARS2 | |
|
[#7]1-[#6]-[#6]2-[#6](-[#6]-1-[#6](= [#8])-[#7]-[#6]-[#6]-[#6]1-[#6]-[#6]-[#6]-1)-[#6]-2 | 1 | R1AB_SARS2 | |
| 5 |
|
[#6]12-[#6]-[#6]3-[#6]-[#6](-[#6]-1)-[#6]-[#6](-[#6]-2)-[#6]-3 | 3 | PPIA_HUMAN |
The structural fragment, SMARTS string, the number of identified hits, and the protein target(s) for which these hits have been found, are given