TABLE 2.
Distribution of β-lactamase, quinolone, aminoglycoside, and cotrimoxazole resistance genes among ESBL-producing E. coli and K. pneumoniae.
|
GPED (199) |
NICU (38) |
PICU (90) |
||||
| E. coli (168) | K. pneumoniae (31) | E. coli (19) | K. pneumoniae (19) | E. coli (67) | K. pneumoniae (23) | |
| No (%) | ||||||
| ESBL genes | ||||||
| blaCTX–M–15 | 142 (84.5) | 31 (100) | 19 (100) | 18 (94.7) | 56 (83.5) | 21 (91.3) |
| blaCTX–M–14 | 8 (4.7) | — | — | — | — | 1 (4.3) |
| blaSHV–106 | — | 6 (19.4) | — | 2 (10.5) | — | 1 (4.3) |
| blaTEM–104 | 5 (3) | — | — | — | 3 (4.5) | — |
| blaCTX–M–102 | 5 (3) | — | — | — | 3 (4.5) | — |
| blaCTX–M–159 | 5 (3) | — | — | — | 2 (3) | — |
| blaCTX–M–3 | 2 (1.2) | — | — | — | 1 (1.5) | — |
| blaCTX–M–27 | 1 0.6) | — | — | — | 2 (3) | — |
| blaSHV–27 | — | 4 (12.9) | — | 2 (10.5) | — | 2 (8.6) |
| blaCTX–M–1 | 1 (0.6) | — | — | — | 2 (3) | 1 (4.3) |
| Other βL genes | ||||||
| blaTEM–1B | 60 (35.7) | 17 (54.8) | 14 (73.7) | 12 (63.2) | 24 (35.8) | 7 (34.8) |
| blaOXA–1 | 23 (13.7) | 17 (54.8) | 5 (26.3) | 8 (42.1) | 7 (10.4) | 4 (17.4) |
| blaNDM 1/5 | 5 (3) | 4 (12.9) | — | — | 2 (3) | 1 (4.3) |
| blaDHA | 6 (3.6) | 2 (6.5) | — | — | — | 1 (4) |
| blaTEM–33/35 | 6 (3.6) | — | — | — | — | 1 (4.3) |
| blaOXA–48 | 4 (2.4) | 1 (3.2) | — | — | 1 (1.5) | — |
| blaCMY | 2 (1.2) | — | — | — | 3 (4.5) | — |
| PMQR-G | ||||||
| aac(6′)-Ib-cr | 21 (12.5) | 14 (45.1) | 3 (15.8) | 7 (36.7) | 8 (11.9) | 4 (17.4) |
| oqxAB | — | — | — | — | 1 (1.5) | — |
| qepA1 | — | — | 2 (10.5) | — | — | — |
| qnr A/B/E/S | 64 (38.1) | 21 (67.8) | 7 (36.8) | 11 (57.9) | 28 (41.8) | 17 (73.9) |
| AME-G | ||||||
| aac(3)-II* | 28 (16.7) | 11 (35.5) | 5 (26.3) | 8 (42.1) | 11 (16.4) | 1 (4.3) |
| aadA1 | 18 (10.7) | 4 (12.9) | — | 2 (10.5) | 10 (14.9) | 1 (4.3) |
| aadA2 | 6 (3.6) | 6 (19.4) | 6 (31.6) | 2 (10.5) | 5 (7.7) | 5 (21.7) |
| aadA5 | 51 (30.4) | 2 (6.5) | 1 (5.3) | — | 22 (32.3) | 1 (4.3) |
| aph(3′)-Ia | 13 (7.7) | 4 (12.9) | — | 2 (10.5) | 2 (3) | 4 (17.4) |
| aph(3″)-Ib | 72 (42.8) | 21 (67.8) | 6 (31.6) | 14 (73.7) | 32 (47.8) | 15 (65.2) |
| aph(6)-Id | 69 (41.1) | 21 (67.8) | 6 (31.6) | 14 (73.7) | 33 (49.3) | 16 (65.2) |
| SXT-RG | ||||||
| dfrA/B | 114 (67.9) | 25 (80.7) | 13 (68.4) | 12 (63.2) | 46 (68.7) | 14 (60.9) |
| sul1-3 | 112 (66.7) | 24 (77.4) | 14 (73.7) | 15 (78.9) | 46 (68.7) | 14 (60.9) |
PMQR-G, plasmid-mediated quinolone resistance genes; AME-G, aminoglycoside-modifying enzyme genes; SXT-RG, cotrimoxazole resistance genes.*Comprised aac(3)-IIa and aac(3)-IId, aac(3)-IVa, and aac(3)-Via.