Table 2.
List of CTL epitopes that have good combined score and are antigenic, nonallergic, and immunogenic, and bind with an affinity IC50 value of less than 200 with the MHC-I alleles.
| Epitopes | Position in sequence | Combined score | Interaction of MHC-I allele with an affinity IC50 value of <200 | Immunogenicity | Antigenic | Allergen | Toxic | Population coverage (%) | Binding score (kcal/mol) of epitopes with MHC-I |
|---|---|---|---|---|---|---|---|---|---|
| FLAFVVFLL | 20 | 1.44 | HLA-A∗02:01 HLA-A∗02:06 HLA-B∗15:02 HLA-C∗03:03 HLA-A∗68:02 |
0.30 | Yes | No | No | 48.4 | −61.8 |
|
| |||||||||
| FLLVTLAIL | 26 | 1.42 | HLA-C∗03:03 HLA-A∗02:01 HLA-B∗15:02 HLA-C∗14:02 HLA-A∗02:06 |
0.17 | Yes | No | No | 48.4 | −57.2 |
|
| |||||||||
| LLFLAFVVF | 18 | 1.25 | HLA-B∗15:01 HLA-A∗32:01 HLA-C∗12:03 HLA-C∗14:02 HLA-B∗15:02 HLA-C∗03:03 |
0.23 | Yes | No | No | 32.5 | −43.31 |
|
| |||||||||
| VLLFLAFVV | 17 | 1.12 | HLA-A∗02:01 HLA-A∗02:06 HLA-C∗12:03 HLA-C∗14:02 |
0.26 | Yes | No | No | 48.4 | −80.3 |
|
| |||||||||
| SVLLFLAFV | 16 | 1.05 | HLA-A∗02:06 HLA-C∗12:03 HLA-A∗02:01 HLA-A∗68:02 |
0.19 | Yes | No | No | 32.5 | −60.31 |