Table 3.
List of HTL epitopes that are antigenic and nonallergic and bind with an affinity IC50 value of less than 200 nm with MHC-II alleles.
| Epitope | Position in sequence | Interaction of MHC-II alleles having IC50 value <200 nm | Antigenic | Allergen | Toxic | IFN-γ epitope prediction | Population coverage (%) | Binding score (kcal/mol) of epitopes with MHC-II |
|---|---|---|---|---|---|---|---|---|
| VLLFLAFVV | 17 | HLA-DRB1∗15:01 HLA-DRB1∗12:01 HLA-DRB1∗04:05 HLA-DRB1∗04:04 HLA-DRB1∗01:01 HLA-DRB5∗01:01 HLA-DRB1∗07:01 |
Yes | No | No | Positive | 53 | −90.4 |
|
| ||||||||
| FLAFVVFLL | 20 | HLA-DRB1∗04:05 HLA-DRB1∗04:04 HLA-DRB1∗15:01 HLA-DRB1∗04:01 HLA-DRB1∗01:01 HLA-DRB1∗07:01 HLA-DRB1∗04:04 HLA-DRB1∗09:01 HLA-DRB5∗01:01 |
Yes | No | No | Positive | 62 | −80.05 |
|
| ||||||||
| LLVTLAILT | 27 | HLA-DRB1∗01:01 HLA-DRB1∗15:01 HLA-DRB1∗07:01 HLA-DRB1∗04:04 HLA-DRB1∗07:01 HLA-DRB1∗04:05 HLA-DRB1∗07:01 HLA-DRB1∗15:01 HLA-DRB1∗11:01 |
Yes | No | No | Positive | 57 | −51.01 |
|
| ||||||||
| LAILTALRL | 31 | HLA-DRB1∗01:01 HLA-DRB1∗15:01 HLA-DRB1∗07:01 HLA-DRB1∗04:04 HLA-DRB1∗04:05 HLA-DRB1∗11:01 |
Yes | No | No | Positive | 57 | −64.52 |
|
| ||||||||
| YVYSRVKNL | 57 | HLA-DRB1∗04:01 HLA-DRB1∗04:05 HLA-DRB1∗07:01 HLA-DRB1∗11:01 HLA-DRB5∗01:01 HLA-DRB1∗01:01 |
Yes | No | No | Positive | 48 | −55.9 |