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. 2020 Nov 24;324(20):1–10. doi: 10.1001/jama.2020.21566

Figure 1. Hazard Ratios for Incident Liver Outcomes Comparing p.C282Y Homozygous Genotype With Individuals With No HFE Variants.

Figure 1.

Hazard ratios adjusted for age, assessment center, genotyping array, and population genetics substructure using principal components. Individuals with each prevalent diagnosis at baseline only were excluded (eg, the incident liver cancer analysis included participants with baseline noncancer liver disease). The participants in the total cohort had incident diagnoses taken from Hospital Episode Statistics, the Cancer Registry, and death records (n = 451 186) (see eTables 4, 5, and 7 in the Supplement for details of all HFE genotypes). Participants in the primary care subset had primary care data available from general practices (n = 209 811).