Table 1. Baseline Characteristics of Participants in a Study of the Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy (N = 451 186)a.
| Characteristics | No. (%) | |||||
|---|---|---|---|---|---|---|
| Men | Women | |||||
| C282Y +/+b | C282Y+/H63D+ | No variants | C282Y +/+b | C282Y+/H63D+ | No variants | |
| Total participants | 1294 | 4955 | 122 860 | 1596 | 5746 | 145 719 |
| Participants with primary care records | 612 | 2297 | 56 425 | 770 | 2754 | 67 916 |
| Age at baseline, mean (SD), y | 56.9 (8.2) | 57.0 (8.1) | 57.0 (8.1) | 56.9 (8.0) | 56.5 (7.9) | 56.6 (7.9) |
| Obesity (BMI >30) | 295 (22.8) | 1223 (24.7) | 31 767 (25.9) | 354 (22.2) | 1353 (23.6) | 33 997 (23.3) |
| Waist circumference, mean (SD), cm | 96.9 (11.1) | 97.0 (11.3) | 97.0 (11.3) | 84.6 (12.5) | 84.9 (12.6) | 84.6 (12.5) |
| Current smoker | 189 (14.6) | 612 (12.4) | 14 953 (12.2) | 138 (8.7) | 509 (8.9) | 12 837 (8.8) |
| Consuming alcohol daily | 324 (25.1) | 1231 (24.9) | 32 471 (26.5) | 256 (16.0) | 932 (16.2) | 24 603 (16.9) |
| Polycythemia (from baseline blood counts)c | 35 (2.8) | 191 (4.0) | 2386 (2.0) | 1 (0.1) | 13 (0.2) | 131 (0.1) |
| Liver enzymes | ||||||
| Alanine aminotransferase >50 U/L [95% CI] | 181 (14.7) [12.8-16.9] | 338 (7.1) [6.4-7.9] | 7197 (6.1) [6.0-6.3] | 62 (4.1) [3.1-5.2] | 139 (2.5) [2.1-3.0] | 3041 (2.2) [2.1-2.3] |
| Aspartate aminotransferase >45 U/L [95% CI] | 129 (10.6) [8.9-12.4] | 226 (4.8) [4.2-5.4] | 4814 (4.1) [4.0-4.2] | 54 (3.6) [2.7-4.6] | 135 (2.5) [2.1-2.9] | 2792 (2.0) [1.9-2.1] |
| Prevalent disease | ||||||
| Diabetes (any type) | 113 (8.7) | 311 (6.3) | 7876 (6.4) | 59 (3.7) | 193 (3.4) | 4478 (3.1) |
| Hepatitis (any) | 5 (0.4) | 24 (0.5) | 675 (0.6) | 5 (0.3) | 30 (0.5) | 648 (0.4) |
| Cirrhosis | 6 (0.5) | 2 (<0.1) | 85 (0.1) | 1 (0.1) | 3 (0.1) | 93 (0.1) |
Abbreviation: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared).
a
p.C282Y heterozygous, p.H63D heterozygous, and p.H63D homozygous individuals are not shown (see eTable 2 in the Supplement for details).
b
HFE p.C282Y homozygosity.
c
Polycythemia defined as elevated hemoglobin (>16.5 g/dL for men; >16 g/dL for women) and hematocrit (>49% for men; >48% for women).20