Table 3.

Univariate and multivariate analysis of factors associated with improvement and decline in renal function at 12 mo

Variables		Univariate analysis		Multivariable analysis
		OR (95% CI)	P	OR (95% CI)		P
Improvement
Age, y			.007			<.001
<70		1.31 (1.07-1.60)		1.58 (1.23-2.04)
≥70		Reference		Reference
Sex			.009			<.001
Male		1.37 (1.08-1.75)		1.62 (1.26-2.09)
Female		Reference		Reference
Baseline dFLC, mg/L
>1000		1.98 (1.53-2.57)	<.001	1.69 (1.28-2.22)		<.001
500-1000		1.06 (0.77-1.46)	<.001	0.98 (0.70-1.36)		<.001
<500		Reference	.70	Reference		.91
Average eGFR, mL/min
<30		2.90 (1.82-4.64)	<.001	3.35 (1.96-5.73)		<.001
30-59		1.69 (1.37-2.08)	<.001	2.23 (1.73-2.87)		<.001
≥60		Reference	<.001	Reference		<.001
dFLC response, %
>90		2.01 (1.18-3.42)	.012	1.92 (1.11-3.34)		.04
50-90		1.53 (0.84-2.75)	.010	1.55 (0.84-2.84)		.02
<50		Reference	.15	Reference		.15
Decline
Age, y			.001		.05
<70	0.70 (0.54-0.84)			0.74 (0.55-1.00)
≥70	Reference			Reference
Sex			.002		.01
Female	1.41 (1.12-1.75)			1.42 (1.08-1.88)
Male	Reference			Reference
Baseline dFLC, mg/L			.14
<500	1.37 (0.99-1.88)		.05	1.33 (0.95-1.86)	.22
500-1000	1.18 (0.80-1.73)		.39	1.23 (0.82-1.83)	.08
>1000	Reference			Reference	.30
Average eGFR, mL/min
<30	1.17 (0.65-2.13)		.15	1.12 (0.55-2.26)	.78
30-59	1.25 (0.99-1.58)		.59	1.10 (0.82-1.49)	.74
≥60	Reference		.05	Reference	.50
dFLC response, %
>90	0.34 (0.22-0.52)		<.001	0.39 (0.20-0.60)	<.001
50-90	0.32 (0.19-0.55)		<.001	0.34 (0.20-0.57)	<.001
<50	Reference		<.001	Reference	<.001

All ORs have been quoted relative to the reference categories. Boldface P values signify statistical significance (P < .05).