Table 1.
Clinical characteristics of nonsplenectomized adult ITP inpatients with and without CAP
| Characteristic | Derivation cohort (n = 1505) | Validation cohort (n = 589) | Difference between derivation and validation cohorts, P | ||||
|---|---|---|---|---|---|---|---|
| With CAP (n = 145) | Without CAP (n = 1360) | P | With CAP (n = 63) | Without CAP (n = 526) | P | ||
| Age at diagnosis of ITP, y | <.001 | <.001 | .571 | ||||
| ≥60, n (%) | 72 (49.7) | 402 (29.6) | 28 (60.3) | 140 (26.6) | |||
| Median | 56.3 | 46.5 | 60.0 | 45.1 | |||
| Type of ITP, n (%) | .718 | .148 | <.001 | ||||
| Newly diagnosed | 43 (29.7) | 384 (28.2) | 31 (49.2) | 309 (58.7) | |||
| Persistent and chronic | 102 (70.3) | 976 (71.8) | 32 (50.8) | 217 (41.3) | |||
| Male sex, n (%) | 74 (51.0) | 465 (34.2) | <.001 | 32 (50.8) | 213 (40.5) | .117 | .014 |
| CCI score | <.001 | <.001 | .991 | ||||
| ≥3, n (%) | 39 (26.9) | 63 (4.6) | 25 (39.7) | 15 (2.9) | |||
| Median (range) | 1.3 (0-6) | 0.6 (0-5) | 1.5 (0-4) | 0.3 (0-4) | |||
| Initial platelet count* | <.001 | .070 | <.001 | ||||
| <20 × 109/L, n (%) | 82 (56.9) | 446 (32.8) | 49 (79.0) | 77 (67.8) | |||
| Median | 24.8 | 38.0 | 14.4 | 15.7 | |||
| Initial ALC† | <.001 | <.001 | .063 | ||||
| <1 × 109/L, n (%) | 89 (66.4) | 199 (16.3) | 46 (74.2) | 83 (18.5) | |||
| Median | 1.1 | 2.7 | 1.1 | 1.8 | |||
*
Fifteen patients (derivation cohort, 3; validation cohort, 12) had no records of initial platelet count.
†
A total of 226 patients (derivation cohort, 148; validation cohort, 78) had no records of initial ALC.