Table 2.
The baseline laboratory parameters in the nonsevere group and severe group of COVID-19 and normal controls
| Variables | Normal controls (n = 60) | Nonsevere group (n = 120) | Severe group (n = 16) | P value |
|---|---|---|---|---|
| Fibrinogen (mg/dl) | 368.00 (290.70–401.00) | 430.50 (361.50–549.25)& | 574.15 (405.30–668.00)&# | < 0.001 |
| Platelet count (× 109/L) | 223.00 (190.25–258.75) | 206.50 (165.00–262.50)& | 155.00 (125.75–206.00)&# | 0.001 |
| WBC count (×109/L) | 5.70 (4.90–6.70) | 5.05 (4.20–6.80) | 5.35 (4.13–7.53) | 0.068 |
| Neutrophil% (%) | 57.95 (53.08–61.68) | 66.50 (59.15–73.48)& | 75.70 (64.53–88.98)&# | < 0.001 |
| Lymphocyte% (%) | 33.30 (28.65–38.98) | 24.45 (18.93–32.08)& | 17.45 (8.23–22.25)&# | < 0.001 |
| NLR | 1.65 (1.35–2.16) | 2.74 (1.88–3.87)& | 4.24 (3.00–10.87)&# | < 0.001 |
| Neutrophil count (×109/L) | 3.28 (2.57–4.09) | 3.30 (2.55–4.39) | 3.89 (2.25–6.57) | 0.539 |
| Lymphocyte count (×109/L) | 1.88 (1.58–2.16) | 1.23 (0.9–1.59)& | 0.74 (0.47–1.18)&# | < 0.001 |
| Sialic acid (mg/dl) | 56.50 (52.85–62.08) | 75.90 (67.8–85.95)& | 85.75 (82.68–97.38)&# | < 0.001 |
| C-reactive protein (mg/L) | 0.67 (0.36–1.71) | 7.71 (1.73–26.59)& | 36.64 (15.33–69.94)&# | < 0.001 |
| Erythrocyte sedimentation rate (mm/h) a | / | 66.00 (38.00–90.75) | 89.00 (60.5–105.75) | 0.071 |
| Angiotensin-converting enzyme (U/L) | 75.00 (57.75–98.50) | 63.50 (51.50–75.75)& | 49.00 (37.25–67.50)&# | < 0.001 |
Data are presented as medians and inter-quartile ranges
P values indicate the comparison among nonsevere group, severe group and normal controls
COVID-19 coronavirus disease 2019, WBC white blood cell, NLR neutrophil-to-lymphocyte ratio
&P < 0.05 versus normal control, #P < 0.05 versus nonsevere group
aThe number of COVID-19 patients who tested erythrocyte sedimentation rate was 114 and 12 in the nonsevere and severe group, respectively, and it was not tested in normal controls