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. 2020 Oct 13;24(21):12341–12354. doi: 10.1111/jcmm.15720

FIGURE 7.

FIGURE 7

Molecular mechanism of MEG3 regulating viral myocarditis (VMC) via the miR‐223/TRAF6/NF‐κB axis. Down‐regulation of MEG3 up‐regulates miR‐223, thus inhibiting TRAF6, inactivating the NF‐κB pathway and blocking the production of IFN‐γ, IL‐6 and IL‐1β, which inhibits polarization of M1 macrophages and boosts polarization of M2 macrophages, therefore, ameliorating myocarditis in VMC mice