Table 1.

Twenty‐seven key differentially expressed gene positively or negatively associated with COPD and each MM

Key genes	Module colour	Cor. COPD	P.GS.COPD	Cor.MM	P.MM	Up or down in three groups
BCL2A1	Black	0.33635796	7.54E‐05	0.903687415	4.27E‐50	Up
CLEC5A	Black	0.37472462	8.84E‐06	0.738236674	3.73E‐24	Up
CCL2	Black	0.39099825	3.27E‐06	0.73301268	1.13E‐23	Up
MMP12	Black	0.41024854	9.38E‐07	0.713224459	5.89E‐22	Up
PROK2	Black	0.28582547	0.000852	0.677410186	3.45E‐19	Up
PLA2G7	Black	0.42014752	4.79E‐07	0.662673241	3.69E‐18	Up
AKR1B10	Green	0.37548358	8.45E‐06	−0.926579463	1.74E‐57	Up
CABYR	Green	0.41976641	4.92E‐07	−0.919968248	3.96E‐55	Up
SLC7A11	Green	0.43590719	1.57E‐07	−0.91364644	4.67E‐53	Up
CYP1B1	Green	0.44622784	7.32E‐08	−0.903934738	3.64E‐50	Up
MUCL1	Green	0.33876692	6.65E‐05	−0.902168494	1.13E‐49	Up
LOC284825	Green	0.40937316	9.95E‐07	−0.895803983	5.68E‐48	Up
GPX2	Green	0.34350277	5.17E‐05	−0.886770489	9.72E‐46	Up
UCHL1	Green	0.34037623	6.10E‐05	−0.8700699	4.53E‐42	Up
ST3GAL4‐AS1	Green	0.38337326	5.24E‐06	−0.84835127	5.39E‐38	Up
ALDH3A1	Green	0.31097422	0.000269	−0.831591653	2.91E‐35	Up
LOC344887	Green	0.34864183	3.91E‐05	−0.824570447	3.31E‐34	Up
AHRR	Green	0.48551789	3.16E‐09	−0.780096563	1.86E‐28	Up
GAD1	Green	0.40581083	1.26E‐06	−0.773455497	1.03E‐27	Up
EGF	Green	0.38090973	6.09E‐06	−0.729019627	2.57E‐23	Up
CYP1A1	Green	0.44206835	9.98E‐08	−0.728558756	2.83E‐23	Up
SPP1	Green	0.36910632	1.23E‐05	−0.682284662	1.53E‐19	Down
LTF	Green	−0.3828154	5.43E‐06	0.680352729	2.12E‐19	Up
STATH	Greenyellow	0.35683960	2.49E‐05	0.620691106	1.60E‐15	Up
TCN1	Greenyellow	0.44571305	7.61E‐08	0.832577273	2.05E‐35	Up
CEACAM5	Greenyellow	0.33658058	7.46E‐05	0.893164229	2.68E‐47	Up
SEMA5B	Yellow	−0.5144968	2.37E‐10	0.737015473	4.84E‐24	Down