FIGURE 3.

Up‐regulation of miR‐497 or down‐regulation of LRG1 increases blood calcium and blood phosphorus levels, reduces urinary calcium, urinary phosphorus, Hyp and ALP levels and lowers OC, BALP, PINP and PICP contents in rats with osteoporosis. A, Urinary calcium and phosphorus levels of rats; B, urinary Hyp of rats; C, blood calcium and phosphorus levels of rats; D, blood ALP content of rats; E, OC and BALP contents in blood of rats; F, PINP and PICP contents in blood of rats; * represented P < 0.05; **represented P < 0.01; *** represented P < 0.001; n = 8. The data were expressed as the mean ± standard deviation. Comparisons among multiple groups were analysed using ANOVA, followed by Tukey's post hoc test for pairwise comparisons