FIGURE 2.

Chronic administration of FGF1 achieves the robust effect on ameliorating adipose tissue inflammation and systemic inflammation. A‐B, The plasma TNF‐α of db/db mice and IL‐6 level in obese mice after chronic treatment with FGF1. C‐D, The immunohistochemical staining of CD68 in epididymal adipose tissue of db/db mice and the quantitative analysis of positive point in tissue sections. E, The relative mRNA level of inflammatory factors in epididymal adipose tissue of db/db mice after chronic administration of FGF1. The data of quantitative analysis were obtained by ImageJ software. Data are presented as mean ± SEM (n = 6). *P < .05, **P < .01, ***P < .001, FGF1 vs db/db. ^# P < .05, ^## P < .01, ^### P < .001, db/db vs db/m