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. 2020 Feb 16;40(1 Suppl):S81–S97. doi: 10.1177/0271678X20902542

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Figure 6. — Senescent microglia are associated with impaired angiogenesis in the aged brain after stroke. (a,b) DEGs related to angiogenesis were explored in both young (a) and aged (b) groups, respectively, in IPA. The genes were indicated by nodes and scatter plotted in different parts of cells. The color of the nodes indicates the expression levels of genes, and the dashed line indicates the predicated activation or inhibition of genes. (c) IPA analysis in young microglia showed that Vegf, Igf1 and Spp1 were predicted as upstream regulators of genes involved in angiogenesis. (d) BrdU (red) and CD31 (green) double staining was performed in both young and aged group 14 days after dMCAO. (e) BrdU⁺CD31⁺ cells were quantified in peri-infarct areas in both cortex and striatum.