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. 2020 May 21;40(1 Suppl):S49–S66. doi: 10.1177/0271678X20925655

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Figure 5. — Transcriptional regulation of tissue remodeling-related genes in aged and young microglia after ischemic stroke. (a) GO enrichment analysis was performed by Metascape on all dMCAO-induced DEGs in young and aged microglia. Shown are the z-scores of biological functions related to tissue remodeling predicted to be strongly activated (z-score > 2) in young microglia after dMCAO. None of them was predicted to be activated in aged microglia (0 < z-score < 2). Enriched biological processes were further classified into three clusters: angiogenesis-related, collagen and adhesion-related, and extracellular matrix-related. (b–d) Shown are the expression profiles of DEGs (fold change > 2, FDR < 0.05) in young microglia which were associated with angiogenesis (b), collagen and adhesion (c), and extracellular matrix (d), with comparison to their expression in aged microglia. *P<0.05 aged dMCAO vs. aged sham.