Table 1A.
Cellular targets antagonized by various SARS-CoV protein.
| SARS-CoV | Proteins of the virus | Cellular targets | References |
|---|---|---|---|
| 1. | Orf3b | Direct inhibitor of IFN-β | Spiegel et al., 2005 |
| 2. | Orf3a | Suppression of IFN signaling (PERK pathway) | Minakshi et al., 2009 |
| 3. | Orf6 | Inhibits IFN signaling by interfering STAT1 | Frieman et al., 2007; Siu et al., 2009 |
| 4. | M and N | Block IFN-I production and NF-κB signaling | Kopecky-Bromberg et al., 2007; Siu et al., 2009 |
| 5. | NSP1 | Inhibit IRF3-STAT1 and NF-κB pathways | Wathelet et al., 2007 |
| 6. | NSP3 | Antagonizes IFN-β | Frieman and Baric, 2008 |